In July 2021, Old Santa Fe Mexican Express found out that its building at 5501 South Broadway in Littleton had been sold to car retailer AutoNation, which planned to demolish the location to make way for a parking lot. After more than two decades in business, the family-run eatery was tasked with finding a new location, which it did — a full year later. In August 2022, it reopened as Old Santa Fe Mexican Grill in a spot just a few minutes away from its original location. Now the entire extensive menu, from the popular chile Colorado to molcajetes and mole, is once again available.